The Pathophysiology of Depression

Introduction to this topic

Presenter:
Professor Carmine Pariante
Professor of Biological Psychiatry, Institute of Psychiatry, London

Updated: Wednesday, 4th September 2019
Last Checked: Wednesday, 4th September 2019 Current

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What is major depression? What are its causes and consequences? How do the brain and the body change when someone is depressed, and how do antidepressants try to tackle these changes? These are the main questions that we are addressing in this module. Ranging from the epidemiology and the social factors underpinning depression, to molecular changes occurring in the brain, we aim to give an overview of why depression is such a burden for society in terms of both morbidity and mortality, and how we can successfully treat this disorder – when we can. Topics include recent genetic and epigenetic studies, the role of early life trauma, neuroplasticity, brain changes at macroscopic and microscopic levels, and changes in the body of depressed patients relevant to the hypothalamic-pituitary-adrenal axis, the immune system and the sympathetic/parasympathetic system. We will conclude discussing classic and novel therapeutic strategies, including the emerging use of biomarkers for a personalised psychiatric treatment.

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Sections in this Topic

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The Pathophysiology of Depression

Duration: 04m 16s
No. of slides: 3 - View Slide List


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The Genetics of Depression

Duration: 07m 43s
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Gene X Environment Interaction and Epigenetics

Duration: 05m 00s
No. of slides: 4 - View Slide List


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Brain Abnormalities in Depression

Duration: 04m 40s
No. of slides: 4 - View Slide List


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Neuroplasticity and Neurogenesis in Depression

Duration: 10m 42s
No. of slides: 6 - View Slide List


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Immune System Abnormalities in Depression

Duration: 07m 00s
No. of slides: 6 - View Slide List


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Is Inflammation the New Frontier for Personalised Medicine in Depression?

Duration: 02m 33s
No. of slides: 3 - View Slide List


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The Hypothalamic-Pituitary-Adrenal Axis in Depression

Duration: 06m 23s
No. of slides: 6 - View Slide List


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The Automatic Nervous System in Depression

Duration: 02m 18s
No. of slides: 3 - View Slide List


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Molecular Mechanisms of Antidepressant Action

Duration: 05m 00s
No. of slides: 3 - View Slide List


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Conclusions

Duration: 00m 47s
No. of slides: 2 - View Slide List