Chlorpromazine, the first antipsychotic medication: history, controversy and legacy

High Royds psychiatric hospital, West Yorkshire, England. This was a typical Victorian asylum. It opened in 1888 and at the end of the 19th century accommodated 1600 patients. The hospital finally closed in 2003.

Introduction The 1950s saw several new classes of medication enter psychiatric practice including the antipsychotics.   The term ‘antipsychotic’ refers to medicines or drugs that are primarily used to treat schizophrenia and bipolar disorder, though some antipsychotics can also be helpful in treating other mental health problems including severe depression. Chlorpromazine was the first antipsychotic and […]

An App a day keeps the doctor away or How training actions can shape attitudes – a new pathway for treating addictive behaviours?

Can apps and computerised tasks change how we interact with the environment and lead to meaningful behaviour change? It sounds too good to be true but evidence suggests that by targeting key cognitive and behavioural processes with specific forms of ‘brain training’ it may be possible. Recent research suggests that training people to repeatedly inhibit […]

BAP guidelines on the management of weight gain, metabolic disturbances and cardiovascular risk associated with psychosis and antipsychotic drug treatment

Introduction In April 2016 the British Association for Psychopharmacology (BAP) published its latest clinical guidelines entitled ‘BAP guidelines on the management of weight gain, metabolic disturbances and cardiovascular risk associated with psychosis and antipsychotic drug treatment’ – subsequent ly referred to in this short article as the ‘Guidelines’.  These Guidelines were drawn up to help […]